2-Chloro-3-amino-4-picoline (CAPIC) is a strategic building block for the preparation of nevirapine, a widely-prescribed non-nucleosidic reverse transcriptase inhibitor for the treatment of HIV-infected patients.A continuous synthesis to the bromo derivative of a CAPIC intermediate, 2-bromo-4-methylnicotinonitrile, that terminates in a edgewater sh
Muscle channelopathies and electrophysiological approach
Myotonic syndromes and periodic paralyses are rare disorders of skeletal muscle characterized mainly by muscle stiffness or episodic attacks of weakness.Familial forms are caused by mutation in genes coding for skeletal muscle voltage ionic channels.Familial periodic paralysis and nondystrophic myotonias are disorders of skeletal muscle excitabilit
In silico investigation of acetylcholinesterase-insecticide interactions in Anopheles stephensi and Anopheles culicifacies using molecular docking
Background & objectives: Malaria remains a significant public health challenge globally, with an estimated 249 million cases reported across 85 endemic countries and regions in 2022, reflecting an increase of 5 million cases from the previous year.Anopheles mosquitoes are the primary vectors responsible for transmitting napoleon concealer malaria p