2-Chloro-3-amino-4-picoline (CAPIC) is a strategic building block for the preparation of nevirapine, a widely-prescribed non-nucleosidic reverse transcriptase inhibitor for the treatment of HIV-infected patients.A continuous synthesis to the bromo derivative of a CAPIC intermediate, 2-bromo-4-methylnicotinonitrile, that terminates in a edgewater shoes dead-end crystallization is described.The route uses inexpensive, acyclic commodity-based raw materials and has the potential to enable lower cost production dea eyewear of nevirapine as well as other value added structures that contain complex pyridines.The route terminates in a batch crystallization yielding high purity CAPIC.This outcome is expected to facilitate regulatory implementation of the overall process.